Association of Vaginal Infection and Preterm Premature Rupture of Membrane

Preterm premature rupture of membranes is still a problem in obstetrics worldwide, including in Indonesia, so that efforts to identify risk factors for preterm PROM are increasingly being researched. This study aims to investigate the relationship between vaginal infection and the incidence of preterm PROM. This research is a cross sectional study conducted on preterm pregnant women. This research was conducted in the Emergency Delivery Room and Obstetrics Polyclinic of Sanglah Hospital Denpasar and Microbiology Laboratory of Sanglah Hospital, from December 2019 to November 2020. Vaginal swab samples were analyzed using gram stain and culture methods. Data was analyzed by using SPSS version 25.0. The total subjects in this study were 54 samples. This study concluded that there was a significant relationship between vaginal infections and preterm PROM (p = 0.002). This study obtained PR = 2.134, so that vaginal infection is a risk factor for preterm PROM. The prevalence of vaginal infection in preterm PROM was 81.48%, while the prevalence of vaginal infection in non-preterm. PROM was 40.74%. The mean age of preterm PROM patients at Sanglah Hospital was 26.85 years; The mean parity of preterm PROM patients at Sanglah Hospital was 3.41 children; the mean gestational age of pre-term PROM patients at Sanglah Hospital was 32.15 weeks; and the mean body mass index of preterm PROM patients at Sanglah Hospital was 27.5 kg/m2. Vaginal infection is risk factor of preterm PROM. Therefore, screening and management of vaginal infections in pregnancy is very important.