The Beta hCG level in the Vaginal Washing Fluid as a Predictor of Premature Rupture of Membrane

Aim: This study aims to determine the relationship between beta-hCG level in vaginal washing fluid with the incidence of premature rupture of membranes (PROM) and the cut-off value of beta-hCG level in vaginal washing fluid in predicting the occurrence of PROM. Materials and Methods: This diagnostic study was carried out in the delivery room of the Emergency Ward, Sanglah Hospital, Denpasar from May 2020 to July 2020. The vaginal wash was taken after delivery and then examined at the Clinical Pathology Laboratory, Udayana University/ Sanglah General Hospital Denpasar Bali. Results: Thirty-five subjects that had met the inclusion and exclusion criteria were involved in this study. The cut-off value of beta-hCG vaginal washing fluid to predict PROM obtained in this study was 118.1mIU/ml with sensitivity of 95.83%, specificity of 81.81%, positive predictive value of 92.00%, negative predictive value of 90.00%, and accuracy of 91.43%. Conclusions: Beta-hCG level in the vagina washing fluid can be used as a predictor of PROM incident. Clinical Significance: The beta-hCG level may be used as a new, fast, non-invasive, promising diagnostic indicator in PROM, thus early prevention and management may be conducted to reduce the morbidity and mortality caused by PROM.