Polymorphisms in Antioxidant Genes GCLM and GPX-4 and Ischemic Heart Disease Development in Kazakhstan Population

Background: This study investigated whether the main antioxidant genes GCLM and GPX4 single nucleotide polymorphisms are associated with Ischemic Heart Disease in people living in Kazakhstan. Methods and Results: We evaluated 166 patients with Ischemic Heart Disease and 172 healthy subjects aged 56 (range 42 – 63). All subjects were genotyped for the presence of GCLM gene promoter polymorphism -588C/Tand GPX-4 718C/T (rs713041) in 3'UTR region.Multiple logistic regression analysis was used to assess differences between age, sex, smoking status and polymorphisms genotyping. In our study GCLM -588TT genotype was significantly associated with the risk of Ischemic Heart Disease (OR=11.75, p=0.02) for general ethnically mixed group; GPX4 718CC geno type also showed a high risk in general group with Ischemic Heart Disease development (OR=2.16, p=0.02). Conclusions: the polymorphism -588TT of GCLM seems to be a strong risk factor for patients with Ischemic Heart Disease in Kazakhstan.