NEFROPROTECTOR EFFECT OF CORN SILK (Stigma maydis) ETHANOL EXTRACT ON GENTAMICIN INDUCED IN WISTAR RATS

Corn silk (Stigma maydis) is one part of the corn plant that contains useful chemical compounds, including flavonoid compounds. This study aimed to determine the nephroprotective effect of corn silk ethanol extract on male white rats. This type of research is an experimental study, where animals were grouped into 5 groups consisting of the negative control group only given 0.5% NaCMC suspension orally, the positive group given gentamicin 80 mg/kgBW intraperitoneally. the treatment group of corn silk extract doses of 250, 500, and 1000 mg/KgBW, the group was given an extract suspension orally for 8 days. On the 3rd day of extract administration, gentamicin was administered intraperitoneally 1 hour after administration of the extract until the 8th day extract administration. On the 8th day urine was collected for microscopic examination and on the 9th day blood was taken from the orbital vein of the eye to measure serum creatinine and urea levels, after that the animals were sacrificed and their ratio of kidney weight and histopathology was calculated. gentamicin showed a significant decrease in serum creatinine and urea levels when compared to the positive control group. Histopathological analysis also showed an increase in cell regeneration and the lowest percentage of tubular epithelial cell damage among other doses. Based on the results of the study, it was concluded that there was a nephroprotector effect on the ethanolic extract of corn silk and a variation of the dose of 1000 mg/KgBW was effective as a nephroprotector.