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A SIMPLE ONE-POT SYNTHESIS OF PYRIMIDO[4,5-C]PYRIDAZINES AND IN SILICO STUDIES OF HUMAN AKT1 INHIBITORS

Journal: International Journal of Advanced Research (Vol.9, No. 10)

Publication Date:

Authors : ;

Page : 136-142

Keywords : One-Pot Synthesis Pyrimido[4 5-c]Pyridazine akt1 Molecular Docking Autodock Vina;

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Abstract

A simple one-pot and efficient synthetic method for the synthesis of pyrimido[4,5-c]pyridazine by a multicomponent reaction. The synthesis compounds are study for their inhibitory activities towards AKT1 pathways by using in silico method. It was found that all compounds have binding energy lower than -7.9 kcal/mol and compound 3a is the most active with binding energy -9.65 kcal/mol, which have been performed using autodock vina.

Last modified: 2021-10-26 19:12:50