Effect of Various Superdisintegrants on Immediate Release Formulations of SGLT2 Inhibitor Canagliflozin

Globally 285 million people and 80 million in India going to get affected in the year 2030 with Type II diabetes. India has become world capital of diabetes. Recently, few novels anti diabetic drugs emerging which belongs to sodium glucose transporter -2 inhibitors (SGLT2). These SGLT2 inhibitors prevent the reabsorption of glucose into blood by the kidney. The present study was under taken to evaluate the effect of various super disintegrants on immediate release of SGLT2 inhibitor Canagliflozin containing formulations. In the present study, total 12 formulations were developed various super disintegrants like Sodium starch glycolate, cross caremellose sodium, pregelatinized starch and Kyron T-314 were used in varying concentration and tablets were prepared by direct compression technique