Orthodontic Management of Patient with Marfan Syndrome - Case Report and Review of the Literature

Marfan syndrome (MFS) is a type of connective tissue disorder caused by a mutation of the fibrillin gene and increased TGF-β in tissues. This disorder leads to connective tissue fragility, with such clinical manifestations as slender fingers, long limbs, abnormal cardiac valves, and aortic aneurysm development. We present here a case of Class II maxillary protrusion in a 13-year-old male with MFS. The patient underwent orthodontic treatment, including extractions of the upper and lower bicuspids. The treatment achieved a good Class I occlusion with normal overjet and overbite. On the other hand, we found extraordinary craniofacial skeleton development during the post-adolescent period and untreatable marginal gingivitis despite complete plaque control, which might be resulted from connective tissue fragility