COL1A1 and COL1A2 Alterations are Associated with Tumorigenesis in Head and Neck Squamous Cell Carcinoma

Background and Aim: Recent studies have shown that alterations of COL1A1 and COL1A2 are associated with various types of cancer, however, the potential oncogenic roles of COL1A1 and COL1A2 in head and neck squamous cell carcinoma (HNSCC) remain largely unknown. Objectives: The aim of the present study was to analyze the expression and genetic alterations of COL1A1 and COL1A2 in HNSCC. Materials and Methods: In the present study, we examined the genetic alterations and expressionof COL1A1 and COL1A2 genes in HNSCC using openly available data from The Cancer Genome Atlas (TCGA). We also analyzed the interaction network, and functional enrichment of COL1A1 and COL1A2. Results: Here, we found that COL1A1 and COL1A2 were highly expressed in HNSCC compared to control tissues. In addition, we identified several pathogenic variants in COL1A1 and COL1A2 genes in HNSCC patients. Therefore, these findings suggest that alterations of COL1A1 and COL1A2 play important roles in the development of HNSCC. Conclusion: The COL1A1 and COL1A2 were highly expressed and frequently altered in HNSCC patients. Therefore, COL1A1 and COL1A2 may be closely related with HNSCC development.