Effect of Green Coffee Bean Extract on Steroid Hormones Synthesis, Blood Lipids and Body Weight in Rats

The aim of this study was to investigate the effect of Green coffee extract on body weight, blood lipids and steroid hormones synthesis on rats. The extracts of green and roasted coffee were prepared using Methanol 80%. 35 rats have been divided to 5 equal groups, the first group was fed by normal diet without supplementing, and the other four groups were fed by high fat diet. The second groups was left without any supplementation while the third and fourth group were fed by 1 ml of green coffee extracts 0.5% and 1% respectively. The fifth group was supplemented by 1 ml of roasted coffee extract 1%. After 6 weeks the weight gain and food intake was calculated and the serum was taken to test blood lipids and ACTH, FSH, LH Hormones. The results showed that the supplementation by 1% Green coffee extract lead to significant decrease in blood lipids and cholesterol, Also it showed significant increase in FSH hormone comparing by other groups. While there is no difference between all groups in ACTH and LH hormones. On the other hand, the high fat diet didn't cause significant change in weight gain compared to regular diet. Coffee analysis showed that the roasting process may lead to liberation of caffeine and decrease in chlorogenic acid content with no difference in phenol content.