THE OMICRON VARIANT BREAKS THE EVOLUTIONARY LINEAGE OF SARS-COV2 VARIANTS

We analyzed 15 genomes and Spikes of the new OMICRON variant, on the one hand 7 from the very first 21K lineage (South Africa, USA, Belgium, Canada), on the other hand 8 from the later second sister-clade 21L (USA, Switzerland, UK). We applied, at the scale of the whole genome and the spike gene, the biomathematics method of Fibonacci meta-structure fractal analysis applied to the UA / CG proportions.There appears a total rupture of this variant with respect to all the previous variants, and a strong differentiation between these 2 OMICRON lines.We have evidenced the RUPTURE of OMICRON with respect to ALL the previous variants: D614G, ALPHA, BETA, GAMMA, DELTA. In particular, we suggest that the mRNA stabilizing secondary structure ("hairpin" conformation) in the spike of all variants is degraded in OMICRON, probably making its mRNA more fragile.The loss of long-range fractal meta-structures in the OMICRON spike gene are in line with common knowledge on the mechanisms of epidemic ending, involving recombination of heavily mutated RNA fragments of the virus, with the possible inference of a distinct helper virus. This would indicate that the SARS-CoV2 is under very strong evolutionary pressure, possibly marking the end of the pandemic.Remarkably, it is observed that the density of OMICRON mutations in the SPIKE PRION region is more than 8 times that of the rest of the Spike protein. This high density of mutations of the Prion region in OMICRON appears to completely suppress this possible Prion function, unlike the Spikes of the various variants and mRNAs vaccines where this Prion function is observed.