The Effect of Pomegranate Extraction (Punica granatum L.) on Albumin Levels and Liver Histology of Male Mice Induced by Paracetamol

Pomegranates had antioxidants such as flavonoids, thus it was assumed to have a hepatoprotective effect. This study aimed to investigate the effect of pomegranate extract on serum albumin levels and histopathological features of male rat liver induced by paracetamol. Pomegranate extract was carried out by the percolation method using ethyl acetate solvent. Some 25 male sprague dawley rats were randomly divided into 5 groups. Pomegranate extract (200 mg / kg body weight and 400 mg / kg body weight) and sylimarin (100 mg / kg body weight) were carried out every day for 15 days, paracetamol was induced 2 hours after administration of pomegranate extract. The parameters measured were serum albumin level and liver histopathology to assess the effect of pomegranate extract on liver damage caused by paracetamol. The results showed that pomegranate extract (200 mg/kg BB dan 400 mg/kg BB) showed that the activity of serum albumin levels was statistically significant (p <0.05) to negative controls and inhibit the damage of liver tissue histopathology of male rats induced by paracetamol. Pomegranate extract showed the effect of hepatoprotector on liver induced by paracetamol.