Medical and Pharmacological Evaluation of Hyperlipidemia and Lipid Profile Status in Iranian Patients with Coronary Artery Disease

The essential role of hyperlipidemia in increasing the risk of cardiovascular disease and its consequences is obvious in all human societies; however, the status of lipid profile may be quite different and even unique in each population. The present study aimed to present a clear view lipid profile status among patients with coronary heart disease in Iranian society. The inclusion criterion for retrieving the studies was the status of lipid profiles among both men and women with a definitive diagnosis of coronary artery disease in Iran. The authors also included a cross-sectional survey on 517 consecutive patients with coronary artery disease and considered the findings in the final meta-analysis. Fourteen studies, including 14437 patients (8633 men and 5804 women) were finally evaluated in terms of the overall prevalence of hyperlipidemia and the serum status of lipid profiles. The pooled prevalence of hyperlipidemia was found to be 39.8% (95%CI: 26.6% to 54.7%) in men and 42.1% (95%CI: 28.5% to 56.9%) in women without between-groups difference (OR = 0.876, p = 0.470). It was found that there is no difference in serum concentrations of triglyceride and total cholesterol; however, our meta-analysis revealed significant differences in serum HDL and LDL levels between men and women. Overall, 39.8% of Iranian men and 42.1% of Iranian women with coronary artery disease suffer from hyperlipidemia, emphasizing uncontrolled lipid profiles in such patients.