FOETUSES ABNORMALITIES CAUSED BYTEGRETOLDRUG ON THEIR PARENTS OF THE ALBINO RAT

The current study was performed to illustrate the harmful effects of different doses of Tegretol (CBZ) which has active ingredient (Carbamazepine CBZ) on the prenatal foetuses of rat at 20th day of gestation. Tegretol (CBZ) noticeably reduced the body weight &length of foetuses in addition the percentage of dead foetuses increased the early mortality of foetuscs which became resorbed besides late foetuses mortality (stillbirth) during the gestation phase. Tegretol (CBZ) administration caused delay of ossification of some bones and shortness of others. Some histo-pathological alterations were founded in livers, kidneys, and lungs of foetuses tissues which parentally administered with different doses of Tegretol (CBZ).