Therapy - Related Myeloid Neoplasms: A Case Report

Introduction: Therapy - related myeloid neoplasms is a neoplasm that occur as a late complication of cytotoxic chemotherapy and/ or radiation therapy administered for a prior neoplastic or non - neoplastic disease. This neoplasm account for 10 - 20% of all cases of myeloid neoplasm. This paper reports a case of a 61 - year - old male with complaints of saddle - back fever for 1 month. The patient previously had a parotid gland malignancy in 2015 and had been treated with radiation therapy for 25 times. Case description: Microscopic examination shows a trephine biopsy consist of trabecular bone with a marrow spaces. Bone marrow shows a hypercellular appearance. Focus of ALIP (abnormal location of immature precursor) can be observed. The hemopoietic cells consist of myeloid, erythroid and megakaryocytic lineage. The erythroid lineage consists of normoblast. The myeloid lineage shows maturation with focus of increased blast count less than 20% (monoblast, myeloblast and promonocyte). Megakariocyte shows prominent hypolobated - micromegakaryocytic features (suggest a dysmegakariopoiesis features). Conclusions: Based on clinical data, laboratory and histopathological examination, the patient was diagnosed with therapy - related myeloid neoplasms.