Applicability of Raw Banana as Super Disintegrant in the Design of Bupropion HCl Orodispersible TabletsJournal: International Journal of Science and Research (IJSR) (Vol.10, No. 11)
Publication Date: 2021-11-05
Authors : Chandini Vegesna; J. Anu Pravallika;
Page : 654-659
Keywords : Orodispersible tablets; Bupropion HCl; sublimation method; superdisintigrants;
The present study was aimed at developing and evaluating orodispersible tablets of Bupropion HCl using raw banana powder as natural superdisintegrant and sodium starch glycolate as synthetic superdisintegrant. Orodispersible tablets were prepared by sublimation method. Effect of superdisintegrants on wetting, disintegration and dissolution parameters were studied. Orodispersible tablets were characterized by Fourier Transform Infrared (FTIR) spectroscopy. Preformulation studies were found as per literature limits. Drug was compatible with superdisintegrants. The prepared tablets were evaluated for weight variation, thickness, hardness, and friability, in vitro dispersion time, wetting time, in vitro disintegration time, drug content and in vitro drug release. In vitro disintegration time decreases with increase in concentration of all superdisintegrants. Among all the formulations BRB5 from raw banana and BSG6 from sodium starch glycolate showed 100% drug release over period of 1 hour. However, among the two optimized formulations, BRB5 with lower concentration of polymer showed effective drug release when compared BSG6 with higher concentration of polymer.
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