HPV Vaccines, Challenges and Complications of Vaccination in Patients with Pre-Existing Diseases

HPV vaccination had been practiced for decades to prevent the development of cervical cancer and is recommended to be routinely vaccinated at 11 or 12 years old. Vaccination against HPV infection has been proven to prevent the transmission of viruses causing diseases effectively. Hence, consequently, it reduces the incidence of cervical cancer. Despite the benefits of vaccination, there are some cases that vaccination against HPV needs intensive concern, especially with the patients who have immunocompromised conditions such as HIV infected patients, rheumatoid (RA) patients, Systemic lupus erythematosus (SLE) patients, and organ transplanted patients. In most cases, HPV vaccination can be administrated routinely as usual while in organ transplanted patients, HPV vaccination had shown to be associated with acute organ rejection.