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Association between Coronary Artery Calcium Score and Clinical Events at 1 Year among Asymptomatic Patients

Journal: International Journal of Science and Research (IJSR) (Vol.10, No. 11)

Publication Date:

Authors : ; ;

Page : 940-969

Keywords : coronary artery disease; coronary artery calcium score; major adverse cardiovascular events; computed tomography; chest pain; coronary angiography;

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Objective: Coronary artery calcium score (CACS) is a well-established test for risk stratifying asymptomatic patients. The study was aimed at estimating the coronary artery calcium score (CACS) and its association with incidence of MACE among atypical chest pain and asymptomatic Intermediate probability CAD patients. Methods: It is a prospective, cross-sectional, observational study. All CT scans were performed on a 256-slice scanner with a 270 millisecond per rotation (Philips Brilliance iCT 256-slice system, Philips Essence Technology). Results: The study was done on 108 patients. Males and females constituted 62% and 38 % respectively of the study population. The mean age of the study population is 54.55 + 7.778 years. In the CACS group-zero were 47 subjects, group 1-99 were 31 subjects, 100-399 were 19 subjects, 400-999 were 10 subjects and more than 1000 were in one. Mean age of male gender in respective CACS group in the study population: CAC group zero ? 51.04 years, 1-99 was 52.05 years, 100-399 was 60.14 years and 400-999 was 61.22 years. With increasing age, there is a linear relationship with incremental coronary calcium score. There were 16 (14.81%) subjects who developed MACE at the end of 1-year follow-up. No MACE occurred in the group with a calcium score of zero. CACS group 1-99 AU had 9.68% events, group 100-399 AU had 26.31%, group 400-999 AU had 70% and group greater than1000 AU had 100% events. It was shown that as the calcium score increases, the risk of events increases. Conclusion: We recommend that in patients asymptomatic and who belong to the intermediate-risk group, suggestive of CAD in whom coronary anatomy is not known, the CACS measurement may be considered the first-line investigation to stratify the risk and assess the risk of MACE. It has the ability to re-classify many into either lower risk, with potential cost-savings in minimizing therapy, or into a higher risk group where appropriate therapies may improve outcomes.

Last modified: 2022-02-15 18:49:35