Differences in Initial Lactate Levels on Elderly and Non-Elderly Sepsis Patients Associated With Sofa Score as a Predictor of Mortality in ICU RSUP H. Adam Malik

Background: Sepsis, a complex syndrome, multifactorial, incidence, morbidity, mortality are increasing. Old age is a predisposing factor due to co-existing comorbidities, repeated hospitalizations, decreased immunity, functional limitations. Hyperlactanemia is a strong independent predictor of death in sepsis. Objective: Know the differences in initial lactate on elderly and non-elderly patients with sepsis associated with the SOFA score as a predictor of mortality. Method: Using a prospective cohort.30 subjects with sepsis who had measured the initial SOFA score, lactate level were taken as samples. The data then analyzed statistically. Results: The difference between the initial lactate of the elderly ? non-elderly was p = 0.724. The difference in the SOFA score was p = 0.089. The difference in initial lactate in dead patients was p = 0.478. The difference in initial lactate in alive was p = 0.226. Significant difference in the initial lactate in elderly patients who died-alive (p = 0.031). Initial lactate was able to predict mortality in elderly patients (p = 0.013). AUC 93.2% (95% CI = 80.2%-100%). Cut-off point (CoP) was 2.1 mmol / L. The initial lactate sensitivity was 81.8%, specificity was 75% in the elderly. Discussion: Women are more than men with severe sepsis had a higher risk of dying in hospital. In elderly, initial lactate of life and death patients, significant differences were found. Conclusion: Initial lactate predicts mortality in the elderly, cut-off point of 2.1 mmol, elderly patients are admitted to the ICU.