Recovery Profile Following General Anaesthesia with Isoflurane in Relation to Body Mass Index and Duration of Anaesthesia in Patients Undergoing Thyroidectomy

Background: Increased BMI may increase the body?s capacity to store potent inhaled anaesthetics, more so with more soluble agents. This study is intended to know whether increased BMI is associated with delay in recovery of verbal response, motor power and cognition after anaesthesia with Isoflurane. Objectives: Primary objective: To study recovery profile following general anaesthesia with isoflurane in patients undergoing total thyroidectomy. Secondary objectives: To study the effect of body mass index and to study the effect of duration of anaesthesia on recovery following anaesthesia with isoflurane. Materials & Method: This hospital based cross sectional study conducted at Dept of Anaesthesiology, Govt medical college, Trivandrum included a total of 96 patients undergoing total thyroidectomy under GA. Outcome variables measured are recovery time in terms of response to verbal commands, adequate motor power and cognition following anaesthesia with isoflurane. RESULTS: The correlation coefficient between BMI & recovery times are 0.51, 0.47 and0.45 respectively indicating moderate correlation. P value above is less than0.001 suggesting that the correlation is highly significant. The correlation coefficient between DOA & recovery times are 0.01,0.033 and0.0 respectively indicating very weak correlation. P value above is greater than 0.05 suggesting that the correlation is not significant. Conclusion: From the present study it can be concluded that there is statistically significant (moderate) correlation between recovery times and BMI. Recovery times in patients with BMIgreater than23Kg/m2 are prolonged as compared to that of with patients BMIless than23 Kg/m2. There was no statistically significant correlation between DOA and recovery times.