A Study for Evaluating Different Doses of Dexmedetomidine in Attenuating Extubation Response in Smoker Patients for Surgeries under General Anaesthesia

Introduction: Smokers are one of the at-risk group of patients prone for developing complications during extubation. Objective: A study for evaluating different doses of dexmedetomidine in attenuating extubation response in smoker patients for surgeries under general anaesthesia. Study design: Prospective randomized study. Method: The present study was carried out and completed on ninety ASA II patients, aged between 40-60 years posted for surgery under general anaesthesia. Total 90 patients who fulfilled our inclusion and exclusion criteria were included in the study and divided randomly into three groups: Group A(n=30) 0.5?g/kg of dexmedetomidine in NS (Total volume 10 ml) Group B(n=30) 0.75?g/kg of dexmedetomidine in NS (Total volume 10 ml) Group C(n=30) 1?g/kg of dexmedetomidine in NS (Total volume 10 ml). Results: The difference in quality of extubation was significant between group A and group B and between group A and group C whereas it was comparable between group B and group C. Suggesting that extubation was better in group B and group C with dexmedetomidine dose 0.75 ?g/kg and 1 ?g/kg respectively. None of the patients had post-operative complications such as laryngospasm, bronchospasm, or severe coughing. None of the patient had respiratory depression. None of the patients had hypotension (MAP less than 65 mmHg or more than 20% decrease in SBP from baseline value or SBPless than80 mm of Hg). Conclusion: We conclude that dexmedetomidine with dose of 0.75 ?g/kg is the best dose for attenuation of extubation response in current smoker patients undergoing major surgery.