Albumin Levels Can as a Predictor of the Severity of COVID-19 Severe-Critical Patients that was Taken in Isolation in Adam Malik General Hospital

Background: COVID-19 is a new disease, the virus that causes COVID-19 is called SARS-CoV-2. Cytokine storms underlie the development of severe COVID-19 disease. Circulating albumin levels are related to the severity of COVID-19 infection. Albumin is a key mediator of immune dysregulation in COVID-19 patients through its immune-suppressing effects and production of pro-inflammatory cytokines that directly contribute to cytokine storm. Methods: This research is an observational study with cross sectional data collection method. This study took blood samples from 39 patients who were treated at the RSUP H. Adam Malik Medan. The sample is checked for Albumin. The research was carried out after obtaining ethical approval and informed consent. Results and Discussion: There were 22 female subjects (56.4%). There were 17 male patients (43.6%). Subjects with severe level were 28 people (71.8%) and with critical level were 11 people (28.2%). Of the 22 female subjects, there were 17 people (77.3%) with severe severity. Using weight spectrophotometry 28 people (71.8%), critically 11 people (28.2%). Albumin levels showed a median of 2.64 g/dL with the lowest level of 1.2 g/dL and the highest level of 3.8 g/dL. The Mann Whitney test showed that there was a significant relationship between albumin and the severity of COVID-19 (p greater than 0.001). Conclusions and Suggestions: There is a significant relationship between albumin and the severity of COVID-19. Further research needs to be done with serial examination of albumin.