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NOVELSYNTHETIC METHOD FOROZENOXACIN
Journal: International Journal of Advanced Research (Vol.10, No. 01)Publication Date: 2022-01-15
Authors : Srinivasa Rao Inukollu Pradipta Sinha Ajay Soni Arani pal; Nageswara Rao Gollapalli;
Page : 644-649
Keywords : Ozenoxacin Cyclopropylamine Suzuki Reaction;
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Abstract
A newsynthetic route has been developed for the total synthesis of ozenoxacin. In this route avoided toxic heavy metals and synthesised the key intermediate_7-bromo-1-cyclopropyl-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid by simply insertion of Cyclopropyl amine into 4-oxo-4H-chromene-3-carboxylic acid intermediate, Then the key intermediate carboxylic acidundergoesSuzuki coupling with boronated ester and deacetylation to afford ozenoxacin.
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Last modified: 2022-02-16 20:19:11