Interplay between Follicle Stimulating Hormone FSH , Luteinizing Hormone LH and Prolactin in Hyperprolactinaemic Infertile Women Treated with Cabergoline in Orlu, Nigeria

The study evaluated the interplay between Follicle stimulating hormones, Leutenizing hormone, and prolactin in hyperprolactinaemic infertile female subjects treated with cabergoline in Orlu, South East Nigeria. Hyperprolactinaemic females who were attending Gynaecology Clinic at Imo State University Teaching Hospital IMSUTH Orlu participated in the study. 30 hyperprolactinaemic females were administered 0.25mg cabergoline twice weekly for eight weeks. Serum prolactin, LH and FSH were assayed before and after treatment using enzyme linked immunesorbent assay ELISA kits. The significant difference between the mean values of prolactin, LH and FSH in the pre and post treatment with cabergoline was determined by paired t test. There was an inverse relationship between prolactin level and FSH and LH before and after treatment. Linear regression analysis showed that for every 0.14 and 0.02 unit change in the level of pretreatment prolactin, there is 1 unit change in FSH and LH level respectively. While for every 0.25 and 0.31 unit change in level of post treatment prolactin, there is 1 unit change in the level of FSH and LH respectively. Only change in post treatment LH following change in post treatment prolactin was statistically significant, and the P value 0.05, however, others were not statistically significant. Ajaero, Oluchi Chinwe | Offiah, Raymond Ogbonna | Unekwe, Prince Chiazor | Ajaero, Nnaemeka Uchendu | Uzoma, Onyeka I. "Interplay between Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH) and Prolactin in Hyperprolactinaemic Infertile Women Treated with Cabergoline in Orlu, Nigeria" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-6 , October 2021, URL: https://www.ijtsrd.com/papers/ijtsrd47720.pdf Paper URL : https://www.ijtsrd.com/pharmacy/pharmacology-/47720/interplay-between-follicle-stimulating-hormone-fsh-luteinizing-hormone-lh-and-prolactin-in-hyperprolactinaemic-infertile-women-treated-with-cabergoline-in-orlu-nigeria/ajaero-oluchi-chinwe