Fuel and Run: Metabolism in Neutrophil Migration| Biomedgrid

Neutrophils are an essential component of the host innate immune system. Migration of neutrophils into inflicted sites composes the primary defense line against pathogens. Recent studies indicate that neutrophils utilize multiple metabolic pathways, instead of only glycolysis. Importantly, neutrophils may preferentially adopt a certain metabolic pathway to adapt to the altered cellular environment or upon various stimuli. In addition, recent studies have shown mitochondrial and TCA cycle are indispensable for neutrophil migration, and here we briefly discuss the regulation of neutrophil migration through cellular metabolism.