The Implication of Hypoxia and Cancer Stem Cells on Tumor Vasculogenesis | Biomedgrid

Tumors vasculature and lymphogensis are crucial for growth and metastasis. Tumor vessels are characterized by irregular structure with higher permeability than normal vessels. This irregularity in shape results in micro-regional hypoxia due to inadequate oxygen supply to tumor cells. Triggered by hypoxia and mediated by Cancer Stem Cells (CSCs), both angiogenesis and Vasculogenic Mimicry (VM) were found in many solid tumors including breast cancer, melanoma, Head and Neck Squamous Cell Carcinoma (HNSCC).