LOW-INTENSITY LASER BLOOD RADIATION AND ITS EFFICIENCY FOR CORRECTION OF HOMEOSTASIS DISORDERS IN PREGNANT RATS WITH THERMAL SKIN BURNS

Background. Treatment of burn injuries is one of the most acute and urgent problems of combustiology, despite all the achievements of modern medicine. With skin burns, multiple systemic changes occur that require special attention and new approaches. Low-intensity laser blood irradiation is a highly effective method of non-pharmacological corrective effect on the homeostasis system of burned patients, but remains unexplored in pregnant women with thermal skin burns. The aim of the research. To evaluate the effectiveness of low-intensity laser blood irradiation for the correction of disorders of the homeostasis system in pregnant rats with thermal skin burns. Material and methods. An experimental study was carried out on 81 female outbred white rats weighing 200-250 g, which were divided into three groups. The control group consisted of pregnant intact rats, the first experimental group - rats with thermal skin burns in the early period of pregnancy, the second experimental group - rats with thermal skin burns in the early period of pregnancy, which underwent low-intensity laser blood irradiation. The oxygen transport function of blood, acid-base status and basic biochemical parameters of blood were studied. Results. Thermal burns of the skin in rats in the early period of pregnancy are accompanied by a deterioration in the oxygen transport function of the blood (a decrease in PO2 and SO2 values, a decrease in the affinity of hemoglobin for oxygen) and the development of metabolic acidosis, as well as the presence of endogenous intoxication (an increase in the concentration of urea and creatinine, an increase in the level of liver enzymes). The use of low-intensity laser irradiation of blood makes it possible to improve homeostasis indices in a shorter time. Conclusions. Low-intensity laser irradiation of blood improves the main indicators of the oxygen transport function of the blood and reduces the level of endogenous intoxication during skin burns in rats in the early period of pregnancy.