Formulation and Evaluation of Ocular in situ gel of Neomycin Sulphate

Conventional dosage forms of Neomycin sulphate suffer from different drawbacks like spillage, poor penetration, low bioavailability, etc. In situ ophthalmic gel can overcome these problems by improving bioavailability, decreasing spillage and diminish the need for recurrent application. Thus, the aim of the present work was to prepare and evaluate in situ ophthalmic gel of Neomycin sulphate for sustained ocular delivery. polymers Carbopol 940 were used in different concentrations for the preparation of Neomycin sulphate insitu gel all formulations were found to be transparent and clear; pH of the formulations was within drug content was found within 94.16% in all optimized in situ gelling systems. Optimized formulations F3 (Carbopol 940), were liquid before instillation to the eye and underwent rapid gelation upon instillation to the eye. Hence, from the above results we can conclude that in situ ophthalmic gels of Neomycin sulphate can be a good option for the treatment of various bacterial eye infections.