Involvement of Oxidative Stress in Type 1 Diabetes | Biomedgrid

Type 1 diabetes mellitus (T1D) is a chronic T-cell mediated autoimmune disease that progressively destroys β-cells in Langerhans islets. T1D develops mainly in children and adolescents. Genetic, immunological and environmental factors are implicated in the mechanisms of β cell death leading to absolute insulin deficiency. ER stress, is also implied in the β cell apoptosis. However, oxidative stress, widely studied for its role in the complications of diabetes, can be pointed out as a most significant factor in the pathogenesis history of T1D. In this review, we present the part of each cited factor in the β cell death with particular attention to the various arguments in favor of the role of early oxidative stress in the development of T1D.