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Involvement of Oxidative Stress in Type 1 Diabetes | Biomedgrid

Journal: American Journal of Biomedical Science & Research (Vol.6, No. 6)

Publication Date:

Authors : ; ;

Page : 538-543

Keywords : Type 1 Diabetes; T1D; β Cell; Oxidative Stress; Apoptosis;

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Type 1 diabetes mellitus (T1D) is a chronic T-cell mediated autoimmune disease that progressively destroys β-cells in Langerhans islets. T1D develops mainly in children and adolescents. Genetic, immunological and environmental factors are implicated in the mechanisms of β cell death leading to absolute insulin deficiency. ER stress, is also implied in the β cell apoptosis. However, oxidative stress, widely studied for its role in the complications of diabetes, can be pointed out as a most significant factor in the pathogenesis history of T1D. In this review, we present the part of each cited factor in the β cell death with particular attention to the various arguments in favor of the role of early oxidative stress in the development of T1D.

Last modified: 2022-04-09 15:40:44