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Synthesis and Characterization of Heterocyclic Compounds Derived from 2-Mercaptobenzothiozole and Study of Their Biological Activities

Journal: Chemical Methodologies (Vol.6, No. 5)

Publication Date:

Authors : ; ;

Page : 409-417

Keywords : Schiff base; حhenyl isothiocyanate; یiazetidine;

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In this study, Schiff base derivatives were reacted with phenyl isothiocyanate and chloroacetic acid to give diazetidine-2-thione and oxazolidinone derivatives. The Schiff base derivatives containing the 2-mercabto benzothiazole moiety were obtained via reaction of a different aromatic aldehyde with 2-(benzothiazol-2-ylthio) acetohydrazide. Furthermore, 2-(benzothiazol-2-ylthio) acetohydrazide were obtained via reaction of 2-mercabto benzothiazole with ethyl chloroacetate, then with hydrazine hydrate. The newly synthesized compounds were characterized via spectral data (FT-IR and 1H-NMR). The antibacterial activity was studied against examples of Gram-positive and Gram-negative bacteria.

Last modified: 2022-04-11 17:11:39