AN ASSESSMENT OF ELASTOSIS IN FIBROCYSTIC BREAST DISEASE AND INVASIVE BREAST CARCINOMA

Fibrocystic disease is one of the most common benign condition of the breast. Its incidence is significantly increased by nulliparity, late age of first birth, and late menopause, factors also associated with increased risk for breast carcinoma risk. Breast cancer is the second leading cause of cancer related deaths in females all over the world. Materials and methods : In the present study 30 cases of fibrocystic disease and carcinoma breast were taken and studied for the presence and grade of elastosis using Hematoxylin Eosin staining and Verhoeff Van Gieson staining. Results : The association between ductal epithelial hyperplasia and grade of elastosis in the Fibrocystic breast disease increased with the severity of the epithelial hyperplasia, but was not statistically significant . The correlation between histological grade of invasive ductal carcinoma-NOS type and grade of elastosis was statistically insignificant, but may be used as predictive marker of response to endocrine therapy.