New Understanding of Fanconi Anemia Signaling Network upon Studying FANCD2 | Biomedgrid

The Fanconi Anemia (FA) pathway is activated upon replication stress and DNA damage. With the accumulated studies, this pathway has emerged as a fundamental signaling network to defend genome stability. The Fanconi Anemia complementation group D2 protein (FANCD2) sits at the center of the pathway, orchestrating many players to prevent our genome from going awry, leading to diseases including cancer. Here, we highlight recent advances in our understanding of FA signaling, emphasizing on a rarely known form of FANCD2, FANCD2-V2.