ROLE OF HYPOMAGNESAEMIA IN PROMOTION OF METABOLIC SYNDROME IN PREMENOPAUSAL WOMEN

Metabolic syndrome (MetS) is a group of disorders indulge into high risk of developing for hyperglycemia, hypertension, obesity and cardiovascular disease (CVD). Studies suggested that low circulatory magnesium levels are related to MetS, type 2 diabetes mellitus (T2DM), and CVD. Present study was planned and designed to find out the association between circulatory magnesium levels and risk for development of MetS. A total of 200 premenopausal women aged 21-45 years were included. MetS was defined by NCEP-ATP III criteria. The biochemical parameters were analyzed on fully autoanalyzer. Data analyzed by using SPSS software, version 22.0 and p<0.05 was considered as statistically significant. Present study highlights that incidence of MetS and hypomagnesemia were 26% and 39% respectively. Circulatory magnesium levels were significantly decreased in study group (with MetS) (1.7±0.3) as compared with control group (2.0±0.5, p<0.001). A significant inverse correlation wasobserved between serum magnesium levels and fasting blood sugar, triglyceride levels, systolic and diastolic blood pressure (p<0.05), whereas a positive correlation with high-density lipoprotein levels were found in study group with MetS. Present study concluded that hypomagnesemia plays a significant role in the pathogenesis of MetS and its associated complications. In view of these findings, supplementation of magnesium improves the status of components of MetS by reducing high blood pressure, hyperglycemia, and dyslipidemia as well.