ANTIOXIDANT ACTIVITY AND CYTOTOXICITY OF POLYFLUORINATED 1, 4- NAPHTHOQUINONES WITH ALKYLATING FUNCTIONS IN THE QUINONE MOIETY

Fluorinated derivatives of 1,4-naphthoquinones are highly potent inhibitors of Cdc25A and Cdc25B phosphatases and growth of tumor cells. Four derivatives of polyfluoro-1,4-naphthoquinone containing alkylating 2-chloroethylthiogroup were synthesized for the first time and their cytotoxicity in human myeloma, human mammary adenocarcinoma, mouse and hamster fibroblasts cells as well as their mutagenic and antioxidant properties in a Salmonella tester strain were studied. All these compounds are effective antioxidants and protect bacterial cells from spontaneous and H2O2-induced mutagenesis. Taking into account these data together with the better cytotoxic effect against cancer cells as compared with normal mammalian cells, protecting of bacterial cells from spontaneous and H2O2-dependent mutagenesis, and low general toxicity towards different cells, one can propose these four compounds can be considered as useful potential antioxidants and inhibitors of tumor cells growth.