RELEVANCE OF PHARMACOGEOMICS IN OVARIAN STIMULATION : A REVIEWJournal: International Journal of Advanced Research (Vol.10, No. 03)
Publication Date: 2022-03-15
Authors : Sonal Navadiya;
Page : 760-768
Keywords : Polymorphism Ovarian Stimulation Pharmacogenetics FSH-Receptor;
Genetic polymorphism is defined as the detection of a single genetic mutation in humans, and in addition each allele should occur at a rate of at least 1% of the population. Potential strategies for detecting various alleles related to specific diseases or responses to drug treatment include case-control studies in uninvolved and affected individuals or genome scanning techniques.Tailoring ovarian stimulation to the individual patient can be challenging because the ovarian response varies substantially between patients. Pharmacogenetics has emerged as a new area of research to improve the balance between desired and undesired actions of drugs, based upon the genetic predisposition of the individual patient. In summary, the use of genomic techniques may not be limited to the rapid and complete detection of drugs. The Ser680 in the gene FSH-receptor has been shown to cause low resistance and low response to FSH action in homozygous women (Ser680 / Ser680). The potential role of AMH in influencing the ovarian response in stimulation. Estrogen plays an important role in the development of secondary sex, fetal growth, the reproductive cycle, and the maintenance of pregnancy.
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