To Study Role of Vaginal Fluid Creatinine for the Detection of Premature Rupture of Membranes

Aim: To study role of vaginal fluid creatinine for the detection of premature rupture of membranes. Material & methods: A total of 80 pregnant women were enrolled in the study Group 1 (control group) consisted of 40 healthy women with no history of leaking per vaginum or leak detected per speculum or per vaginum examination and Group 2 (case group) consisted of 40 women with history of leaking per vaginum or leak detected per speculum or per vaginum examination. All patients were sampled for vaginal fluid creatinine by speculum examination. Sample processed. Vaginal fluid creatinine level was estimated andcompared for its significance. Receiver operating characteristic (ROC) curve analysis was used to establish the optimal cut-off concentrations for vaginal fluid creatinine, its cut off, accuracy, sensitivity & specificity. Result: The mean vaginal fluid creatinine in case group was 0.42+0.1 mg/dl and 0.18+0.08 mg/dl in control group respectively and its difference was statistically significant (pless than0.001). The optimal cut off value was greater than0.25 mg/dl with 90% sensitivity, 87.5% specificity & 91.6% accuracy for diagnosis of PROM. Conclusion: Vaginal fluid creatinine is a rapid, simple, inexpensive, non-invasive & widely available test so that it can be easily incorporated in routine clinical use when the diagnostic dilemma of PROM is present.