Ovulation Induction and Clinical Pregnancy with Letrozole Alone and in Combination with Inj HMG in PCOS Related Infertility Patients: A Prospective Study

The aim of study was to compare letrozole alone versus letrozole in combination with HMG for ovulation induction and clinical pregnancy in PCOS Patients. Materials and Methods: A total of 150 consecutive patients were enrolled in the study and were divided into two groups. Group "A" (n=75) received letrozole alone. Group "B" (n=75) received letrozole as well as 75 IU HMG. Transvaginal ultrasound was done for follicular growth monitoring. Ovulation was triggered by an intramuscular injection of 5,000-10,000 U of human chorionic gonadotropin (HCG). On the same day LH, E2 and progestrone levels were measured. Signs of Ovulation were confirmed by TVS. After treatment, the clinical pregnancy (including normal pregnancy and abortion), multiple pregnancy and average medication cycle of clinically pregnant patients of the two groups were compared. Results: Both the groups received treatment of ovulation induction for 4 to 6 cycles or till pregnancy was confirmed, which ever one was earlier . The pregnancy rate of the Group B was 54.7 %, which was significantly higher than that of the Group A (29.3 %). This difference was statistically significant (Pless than0.05). Conclusion: Letrozole in combination with low-dose HMG on alternate days shows good results in PCOS related infertility patients and had a satisfactory effect on ovulation and high clinical pregnancy rate in these patients.