Evaluation of Biochemical Parameters under Oxidative Stress in Experimental Rats Exposed to Cadmium toxicity and the Protective Role of Zinc and Vitamin C

Aim: In the present study we aimed to determine the protective effects of Zinc and Vitamin C both individually and in combination in diminishing the biochemical changes in the test tissues (liver and kidney) under Cadmium (Cd) intoxication. Method: For this purpose, Wistar strain male albino rats were treated with Cadmium Chloride (CdCl2) at a dose of 1/10th LD50 / 96 h i. e.22.5 mg/Kg body weight for an experimental period of 7, 15 and 30 day time interval. Then 15d Cd treated rats were divided into three groups. The first group received Zn (12 mg/Kg) alone, second group Vitamin-C (200 mg/Kg) alone and a third group received both Zn and Vitamin-C again for 7, 15 and 30 d long sojourn. Results: Cd induced toxicity rats showed significant changes in serum biochemical parameters along with concomitant increase in LPO content. Further Zn and Vitamin-C supplementation to Cd-treated rat tissues showed decrease in the biochemical parameters. Conclusion: From the present study we conclude that Zinc and Vitamin C are prominent nutrients that alter the biochemical processes and decrease the Cd body burden. Zn and Vitamin C supplementation either individually or in combination showed much protective effects in combating Cd stress in selected test tissues of male albino rat.