PEMPHIGOID GESTATIONIS : CASE REPORT AND REVIEW OF LITTERATUREJournal: International Journal of Advanced Research (Vol.10, No. 03)
Publication Date: 2022-03-15
Authors : Badsi Safae Louzali Fatima Zahra Benaouicha Nisrine Zeraidi Najia Lakhdar Amina Kherbache Aicha; Baidada Aziz;
Page : 1065-1069
Keywords : ;
Pemphigoid gestationis (PG) is a rare autoimmune bullous dermatosis associated with pregnancy. Its previous designation, herpes gestationis, is obsolete. PG is characterized by a subepidermic separation induced by the presence of peripheral blood autoantibodies against two hemidesmosomal antigens: BPAG1 and BPAG2. Clinical diagnosis is confirmed by histology and positive cutaneous immunofluorescence tests. The most discriminant examination for other pruritic dermatoses of pregnancy is the enzyme-linked immunosorbent assay (Elisa) NC16A BP 180. First-line treatment is local corticosteroid therapy if local treatment fails, general corticosteroid therapy should be administered. The prognosis is good for mother and child, except that there is a risk of preterm delivery and of moderate fetal growth restriction. Management in a specialized setting is therefore necessary. Recurrence is possible during subsequent pregnancies. We report a case of PG identified in our department, with a review of literature about physiopathology, diagnosis and treatment of this rare pathology.
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