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Immune reactivity features in post-burn dynamics

Journal: RUDN Journal of Medicine (Vol.26, No. 2)

Publication Date:

Authors : ; ; ;

Page : 194-202

Keywords : thermal injury; “burn” stress; cellular and humoral immune units; immune imbalance; activation; suppression;

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Relevance. To date, burn injury remains a complex type of damage to skin tissues. Along with local destructive and dystrophic phenomena, systemic changes in the body are observed. The aim of the study was the experimental study of the immune reactivity of the body of nonlinear rats under conditions of “burn” stress formed as a result of contact thermal trauma. Materials and Methods. The study was carried out on non-linear male rats with an average mass of 220 gr. The functional activity of the immune system of laboratory animals was evaluated on the basis of standard tests assessing the adaptability of the immune system. Results and Discussion. In an experimental study, it was found that in the dynamics of burn injury in laboratory animals, variable changes in the body’s immune reactivity were observed at the level of the cellular and humoral links of immunity, which was manifested by a decrease in the WGST index and an increase in the following indicators - antibody titer, phagocytic index (FI), phagocytic number (FF), leukocytic coefficient and number of leukocytes. The increased content of stick-n uclear forms indicated the activation of granulocytopoiesis, which determined the deregenerative nuclear shift of neutrophil granulocytes to the left. Along with these changes, a decrease in the mass of immune organs (thymus and spleen) was observed, which can be explained by the expression of accidental involution caused by intoxication against the background of a thermal burn. Conclusion. Under conditions of “burn” stress, an immune imbalance occurs in the form of activation of some and suppression of other links at different observation times. Thus, during the burn process, systemic immune changes taking place at the body level have a multi-d irectional dynamic character, which indicates the adaptive capabilities of the immune system.

Last modified: 2022-05-28 06:23:35