FORMULATION AND EVALUATION OF CYCLOSPORINE LOADED CUBOSOMES FOR THE MANAGEMENT OF PSORIASIS

Cubosomes can be considered as novel lipid-based nanosystems similar to well-known vesicular systems such as liposomes and niosomes. Cubosomes have been widely formulated using certain amphiphilic lipids (e.g. glyceryl monooleate and phytantriol) in the presence of a suitable stabilizer. They can represent a novel drug delivery system which could be loaded with hydrophilic, lipophilic and amphiphilic drug molecules. They are widely used for various drug delivery applications such as oral, ocular, transdermal and chemotherapy drug delivery. In this study, preparation and characterization of cyclosporine loaded cubosomes have done for the management of psoriasis. The preformulation study and formulation of cubosomes was performed. Evaluation parameters of the cubosomes were performed and results were reported.