Antiproliferative Effects of Origanum syriacum L. and Myrtus communis L. on Human Colon Cancer Cell Line

In this study, we aimed to investigate the composition and antiproliferative efficacy of Origanum syriacum L. and Myrtus communis L. essential oils on the HCT cell line. Also, it was aimed to search the synergistic activities of Origanum syriacum L. and Myrtus communis essential oils with MTX (Methotrexate) on HCT 116 cells. The main essential oil components of Origanum syriacum L. were Thymol (42,18%), Carvacrol (33,95%), Cymene (8,87%), γ-Terpinene (8,21%) and for Myrtus communis L. the main essential oil components were Eucalyptol (45,41%), α-Pinene (20,86%), Linalool (9,71%). In this study, HCT 116 human colon cancer cell line and Vero cell line were used. To determine the non-cytotoxic concentration of Origanum syriacum L. and Myrtus communis L. essential oils Vero cell line was selected. The cytotoxic activity of the essential oils was measured using the MTT method and the results were evaluated as IC50. The Inhibition concentrations of the essential oils of Origanum syriacum L. and Myrtus communis L. essential oils against cancer HCT 116 and Vero cells were evaluated. It has been found that the essential oils of the Origanum syriacum L. and Myrtus communis have an important antiproliferative effect on human colon cancer cells. In our study findings, we think that these two plant essential oils may be a potent drug active compound for cancer treatment.