Autism Spectrum Disorder and Co-morbidities: A Closer Look at Pathogenesis and Clinical Implications | Biomedgrid

The overlap in clinical manifestation of Autism Spectrum Disorder (ASD) and its psychiatric co-morbidities, including Schizophrenia (SCZ), are frequently overlooked. In this review, we enumerated the genetic markers, signs of inflammation and gut-microbiome-brain signatures, and excitation/inhibition imbalances shared by ASD and SCZ. We also summarized advancements in early detection as a result of the predictive value of certain biomarkers and in the development of evidence-based emerging treatments for ASD and co-morbidities.