Liver Cirrhosis and Neurological Disorder Associated with Liver Disease

Normal brain function is closely and comprehensively related to normal liver function. Not only the liver plays an important role it supplies essential nutrients to the brain, but also to detoxify splanchnic blood. Impaired liver function thus leads to insufficient detoxification allowing neurotoxins such as ammonia, manganese and other chemicals to enter the brain. In addition, postosystem short circuits, ie common complications in advanced liver disease, facilitate the free transfer of neurotoxins into the brain. The problem has increased furthermore, due to other variables such as gastrointestinal bleeding, malnutrition and related kidney failure, which are often associated with the liver cirrhosis. Neurological damage in chronic liver disease and cirrhosis of the liver appear to be several major causes like the brain accumulation of ammonia, manganese and lactate, altered permeability of the blood brain barrier, monocyte recruitment after microglial activation and neuroinflammation i.e. the direct effects of circulating systemic proinflammatory cytokines such as tumor necrosis factor, IL 1ß, and IL 6. hepatocerebral degeneration, hepatic myelopathy, cirrhosis related parkinsonism, cerebral infections, bleeding and osmotic demyelination. In addition, neurological complications can occur exclusively in some diseases, such as Wilsons disease, alcoholism Wernickes encephalopathy, alcoholism .cerebellar degeneration, Marchiafava Bignami disease, etc. . The radiologist should be aware of their various clinical manifestations and radiological manifestations because the diagnosis is not always immediate. Medicaments should be aware of the problems of neurological complications that can occur in liver disease, including hepatic encephalopathy. Panshul Sharma | Dr. Kapil Kumar Verma | Mr. Hans Raj "Liver Cirrhosis and Neurological Disorder Associated with Liver Disease" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-6 | Issue-4 , June 2022, URL: https://www.ijtsrd.com/papers/ijtsrd50196.pdf Paper URL: https://www.ijtsrd.com/pharmacy/pharmacognosy-/50196/liver-cirrhosis-and-neurological-disorder-associated-with-liver-disease/panshul-sharma