Formulation Development and Evaluation of Tablet Formulation Containing Ibuprofen HCL with Castor Oil

The purpose of this study was to formulate and evaluate conventional tablets of Ibuprofen HCl with Castor oil. Castor oil helps to overcome the hepatotoxic effect of Ibuprofen HCl. Direct compression method was used to formulate tablets, which contained Castor oil in different proportion from batch F1 F4. Formulation of tablets was prepared by the powder blend of different ratios of Castor oil to get desirable drug release profile. All batches were evaluated for flow property Pre compression study . Evaluation parameters of formulated tablets were hardness, friability, thickness, drug content, weight variation, and the in vitro drug release rate pattern. Results indicated that the formulation F2 was the most promising formulation as the drug release from this formulation was high as compared to other formulations. In formulation F2, percentage drug release of Ibuprofen HCl is 97.01 at 60 min. Gayatri Burte | Vikram Veer | Ashok Bhosale "Formulation Development and Evaluation of Tablet Formulation Containing Ibuprofen HCL with Castor Oil" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-6 | Issue-4 , June 2022, URL: https://www.ijtsrd.com/papers/ijtsrd50389.pdf Paper URL: https://www.ijtsrd.com/pharmacy/other/50389/formulation-development-and-evaluation-of-tablet-formulation-containing-ibuprofen-hcl-with-castor-oil/gayatri-burte