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Protective Effect of Afang (Gnetum africanum) Vegetable Inclusive Diet in Cyclophosphamide-Induced Oxidative Stress in the Brain of Male Wistar Rats

Journal: Journal of Food Stability (Vol.5, No. 1)

Publication Date:

Authors : ;

Page : 1-11

Keywords : Afang; neurodegeneration; antioxidant; endogenous enzymes; malondialdehyde;

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Afang (Gnetum africanum) leafy parts are used in fore lore medicine and in soup preparation. The protective effect of dietary inclusion of Afang (2 and 4%) inclusive diet on cyclophosphamide (75 mg/kg body weight) induced oxidative stress in rat's brain was assessed on endogenous enzymes parameters. The dietary inclusion caused a significant (p<0.05) decrease in malondialdehyde (MDA) produced in rat's brain while the key enzymes linked to neurodegeneration such as acetylcholinesterase, butylcholinesterase and monoamine oxidase activities decreased significantly when compared to cyclophosphamide-induced and the Donepezil groups as a result of the diet-inclusion. Also, there were reduction in alkaline phosphatase and aspartate amino transferase activities with an increase in catalase activity and vitamin C content, which indicates its high antioxidant properties. Afang leafy vegetable is rich in bioactive compounds and could be used to manage neurodegenerative diseases.

Last modified: 2022-10-02 18:57:47