Synthesis and Biological Study of Some Transition Metal Ions Complexes of Schiff-Mannich Base Derived from 2- amino-5-mercpto -1,3,4 thiadiazole

Schiff –Mannich base derived from 1,3,4 thiadazole prepared by combining of 2-amino-5-mercapto-1,3,4 thiadazole and 4-N,N-dimethyl benzaldehyde with indol . The result compound is 5-( (1 H - ind ol - 1 - yl ) methylthio ) -N - (4 - ( dimethylamino ) benzylidene ) -,1,3,4-thiadiazol - 2 – amine(L),coordinated with six metal ion Co (II), Ni(II), Cu(II), Pd(II) and Pt(IV), Au(III) .The ligand (L) has been characterized using the following techniques, C.H.N.S, FTIR, UV-ViS,1HNMR, 13CNMR.in addition to the measurement of ( atomic absorption spectra ,magentic susceptibity and molar conductivity) were used when diagnosing the complexes. Experimental results showed that the ligands coordinated as tri-dentate with metal ions. The antibacterial and antifungal activity of all complexes were studied against Staphylococcus aureus and Bacillus subtilis as a model of gram positive, E- coli and Klebsiella pneumoniae as a gram negative at one concentration 0.02 M . Determine the effectiveness of the prepared compounds in inhibiting selected types of bacteria and fungi. The results showed that the prepared metal complexes and ligand are more effective than the standard drug in bacteria and fungi. The ratio of metal to ligands was determined by the molar ratio method and showed the interaction of the metal with the ligand proportion (1:1). Also, the compounds prepared were studied in gas phase using the hyper-chem8.0.7 program. Through this program, the heat of formation, binding energy, HOMO and LUMO, electrostatic potential in addition to the infrared vibration of the ligand were calculated.