Formulation and Evaluation of Multiple Emulsion of Repaglinide

Repaglinide (Prandin) is an oral insulin secretagogue of the meglitinide class (Antidiabetic) of BCS Class ІІ has low bioavailability. It is used to treat type 2 diabetes (condition in which the body does not use insulin normally and, therefore, cannot control the amount of sugar in the blood). The Multiple Emulsion is the complex polydispersed system in which an emulsion is incorporated in another emulsion therefore they are also known as “Emulsion of Emulsion”. The aim was to prepare a stable Multiple Emulsion of Repaglinide by incorporating various hydophilic and lipophilic surfactants at different concentrations. The characterization of drug sample was done using spectrophotometric analysis and melting point determination. All the observations and recorded data were identical to the values reported in literature. Calibration curves of Repaglinide in 0.1N HCl and phosphate buffer (pH 7.4) were prepared using a double beam UV-visible spectrophotometer (Shimadzu 1800)The different formulations of multiple emulsion were evaluated on the basis of their drug entrapment efficiency and stability. The multiple emulsion was stable and had good entrapment efficiency. There were no drug-excipients interactions. From the result and conclusion of the research work we can summarize that the multiple emulsions can be optimized for good stability and higher entrapment efficiency by optimizing different formulation variables like type and proportion of primary and secondary emulsifier incorporated in Primary Emulsion and Multiple Emulsion.