Green Synthesis of Biowaste Derived Pectin from Pomelo Citrus Maxima Peel and Cacao Theobroma Cacao Pod Husk as Potential Pharmaceutical Excipient

Recent developments in pharmaceuticals include the emergence of orally disintegrating tablets ODTs which offers a novel way of administering oral medication to patients suffering from dysphagia or difficulty in swallowing. This study aimed to obtain biowaste derived pectin from pomelo Citrus maxima peels and cacao Theobroma cacao pod husks and evaluate its potential as disintegrant in ODTs. Furosemide was used as the model drug in this study. Through acid extraction process, pomelo and cacao yielded 3.66 and 2.80 of pectin, respectively. Furosemide, glucose, talc, crospovidone, and pectin were used in four ODT formulations through direct compression method. The process produced 40 tablets for each formulation. These were then evaluated in pre and post compression parameters. Results showed that Carr's index 10.46 to 18.75 , Hausner's ratio 1.12 to 1.23 and angle of repose 31.64 to 40.62 as pre compression parameters indicated that the powder blends were of good compressibility and flow ability characteristics, ensuring mixture homogeneity and their suitability for compression. As per post compression parameters, tablets from different formulations had acceptable and insignificant weight variation ±7.5 and tablet thickness ±5 which meant that uniform tablets were produced. Moreover, tablets with cacao pectin showed superior performance in terms of wetting time 13s , water absorption ratio 47.95 and disintegration time 73s over tablets with pomelo pectin and crospovidone, a synthetic disintegrant. The hydrophilicity and good water uptake of pectin aided in the disintegration of the tablets. It was concluded that biowastes can be sources of pectin and that cacao pectin is a potential tablet disintegrant in ODTs. Joanna Marey F. Mondejar | Jean Ailyn O. Pitolan "Green Synthesis of Biowaste-Derived Pectin from Pomelo (Citrus Maxima) Peel and Cacao (Theobroma Cacao) Pod Husk as Potential Pharmaceutical Excipient" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-6 | Issue-7 , December 2022, URL: https://www.ijtsrd.com/papers/ijtsrd52342.pdf Paper URL: https://www.ijtsrd.com/other-scientific-research-area/other/52342/green-synthesis-of-biowastederived-pectin-from-pomelo-citrus-maxima-peel-and-cacao-theobroma-cacao-pod-husk-as-potential-pharmaceutical-excipient/joanna-marey-f-mondejar