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Evaluation of interactions of silibinin with the proteins ALS3 and SAP5 against Candida albicans

Journal: Journal of Health and Biological Sciences (Vol.10, No. 1)

Publication Date:

Authors : ; ; ; ; ; ; ;

Page : 1-6

Keywords : silibinin; fungal infection; candida spp; molecular docking; adhesion proteins;

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Objective: to evaluate the molecular interaction of silibinin with the targets ALS3 and SAP5. Methodology: Molecular docking protocols were conducted to analyze the binding interaction of silibinin with ALS3 and SAP5. Results: Eleven interactions of ALS3 with silibinin and four with fluconazole were found, while six interactions were observed of SAP5 with silibinin and four with fluconazole. Conclusion: Molecular docking between silibinin and ALS3 identified important interactions, but no significant interactions were observed with SAP5, even though silibinin can exhibit affinity and interactions with other SAP5 sites.

Last modified: 2023-01-21 05:55:02