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Solvent wetting method- A novel approach for preparation of Felodipine solid dispersion

Journal: International Journal of Pharmaceutical Sciences Letters (Vol.2, No. 6)

Publication Date:

Authors : ; ;

Page : 163-166

Keywords : Felodipine; Solid dispersion; Solvent wetting method; Dissolution; Poorly water-soluble;

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(FEL) solid dispersions in the presence of various carriers i.e. Polyvinyl pyrrolidone (PVP), Hydroxy propyl methyl cellulose (HPMC) and poloxamer. Methods: The ethanol was used for the wetting of the mixture of drug and carriers. The amount of ethanol used to prepare solid dispersions (SDs) did not have a significant effect on the dissolution rate of FEL. Results: The results of differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD) indicated that the drug was in the amorphous state when PVP, HPMC, and poloxamer were used as carriers. The dissolution rates of FEL in PVP, HPMC and poloxamer solid dispersions were much faster than those for the corresponding physical mixtures. Conclusion: Dissolution profiles were found to depend on the carrier used; the dissolution rate of FEL increased slowly for solid dispersions prepared using HPMC, whereas rapid initial dissolution rates were observed for solid dispersions prepared using PVP and poloxamer. Increases in dissolution rates were partly dependent on the ratios of felodipine to carrier. No significant changes in crystal form were observed by powder X-ray diffraction (PXRD) or differential scanning calorimetry (DSC).

Last modified: 2013-06-03 18:08:07